Synthesis of Biologically Potent -Aminophosphonates

Amongst phosphorus compounds, aminophosphonates and their derivatives have received considerable attention in recent years because they exhibit intriguing biological activities. -aminophosphonate derivatives are gaining lot of importance in medicinal chemistry due to their applications as enzyme inhibitors, pharmacological agents , herbicides , antibiotics and inhibitors of Excitatory Post- Synaptic Potential (EPSP) synthase and HIV Protease . -Aminophosphonic acids seem to be even closer analogues of their -amino phosphonic counter parts due to their monobasic/acidic character and higher stability of the P-C bond of phosphonicacids compared with the P-O bond. Due to its medicinal importance such as anti-cancer, anti-HIV, antithrombotic and antibacterial properties, lot of reviews are needed to guide the reader into this fascinating aspect of phosphorus chemistry. This book has been initiated with this motto.

Autorentext

Dr. S. Santhisudha, Department of Chemistry, Dravidian University Kuppam is a National Post-Doctoral Fellow through SERB-DST, India and a recipient of Young Scientist Award 2017 and 2016 by Venus International Foundation and A. P. Akademi of Sciences respectively. Her research interest is synthesis of bioactive organic molecules.