Synthesis & Biological Activity s-Triazine

Triazine is the chemical species of six-membered heterocyclic ring compound with three nitrogens replacing carbon-hydrogen units in the benzene ring structure. The names of the three isomers indicate which of the carbon-hydrogen units on the benzene ring position of the molecule have been replaced by nitrogens, called 1,2,3-triazine, 1,2,4-triazine, and 1,3,5-triazine respectively. Symmetrical 1,3,5-triazine is the common. Triazines are prepared from cyanic acid amide by trimerization (1,3,5-triazine). Triazines are weak base. Triazines have much weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution. Heterocyclics bearing a symmetrical s-triazines or 1,3,5-triazines moieties, represent an interesting class of compounds possessing a wide spectrum of biological activities such as anti-cancer, antiviral, fungicidal , insecticidal, bactericidal, herbicidal and antimicrobial, antimalarial agents. They also find applications as dyes, lubricants and analytical reagents.

Autorentext

Deepak Kumar Basedia is working as Asst. Professor, Department of Pharmaceutical Chemistry, T.I.T. College of Pharmacy, Bhopal (M.P.), India. He has completed his M. Pharm., Pharmaceutical Chemistry from SRM College of Pharmacy, SRM University, Chennai and currently pursuing Ph. D. at JNU Jaipur.