Systems Biology of Tumor Physiology

This exciting SpringerBrief presents evidence for new ideas that will challenge several theories of how cancer biology is understood. Cancer biology has undergone several intellectual revolutions in the past 50 years. A mutation-centric view of cancer has given way to the tumor microenvironment view. Reductionistic studies of one gene at a time have given way to systems biology approaches that analyze the whole genome (omics) at the same time. However, this text combines the complex levels studying cancer at the molecular biology level, endocrinology level, and transcriptomics level. What researchers are now realizing is that there is a need to combine omics with physiology concepts in order to better understand cancer and this book will give insight to the merging of these two fields in order to define how cancer is studied in the future.

Discusses 'cell origin' versus 'plasticity' hypothesis in cancer Explores how to use mouse models in cancer research Provides a unique perspective by merging physiology and system biology view of breast cancer Includes supplementary material: sn.pub/extras

Autorentext

David H. Nguyen, Ph.D., received the Department of Defense Pre-Doctoral Fellowship in Breast Cancer Research while conducting doctoral research at the University of California-Berkeley and Lawrence Berkeley National Laboratory. He then did post-doctoral research jointly between New York University and Lawrence Berkeley National Laboratory. He is a lecturer for the Integrated Science Program that is part of Southern California University of Health Sciences. He is also the founding editor-in-chief of Cancer InCytes Magazine. His research interests are the hormonal, immune, and epigenetic mechanisms behind why childhood trauma correlates with an increased risk of cancer during adulthood.