Tailor-Made and Functionalized Biopolymer Systems

Tailor-Made and Functionalized Biopolymer Systems: For Drug Delivery and Biomedical Applications covers the design and application of these functionalized and tailor-made biopolymers and biopolymer systems intended for drug delivery and biomedical applications. Various concepts, design protocols and biomedical applications of tailor-made biopolymer systems are covered, guiding the reader from theoretical knowledge to practical application. Authored by an array of experts from global institutions, this book offers an interdisciplinary approach to how tailor-made biopolymers lead to novel drug delivery and treatment solutions. This will be a useful reference to a broad audience, including biomedical engineers, materials scientists, pharmacologists and chemists.

Autorentext
Dr. Hriday Bera completed his Masters study at Jadavpur University, Kolkata, India and Ph.D at National University of Singapore, Singapore. He is presently working as Post-doctoral Fellow at Shenyang Pharmaceutical University, China and Nano Medical Engineering Laboratory, RIKEN, Wako, Japan. The major focus of his current research is the conceptual design, fabrication and evaluation of chemically modified naturally-occurring polymer based systems intended for drug delivery and other biomedical applications. As a part of his research career, he published 36 peer-reviewed articles (including 23 first-author articles) in various international journals of repute with a total SCI citation of 546, h-index of 15 and i10-index of 20. Moreover, he penned 20 book chapters for various international publishers. Furthermore, as a principal investigator, he has received highly competitive research grants from AICTE, Govt. of India; Ministry of Higher Education, Govt. of Malaysia; National Natural Science Foundation, China and Tekada Science Foundation, Japan. Dr. Buddhadev Layek received his Master of Pharmacy degree from Jadavpur University in Kolkata, India and Ph.D. in Pharmaceutical Sciences from North Dakota State University in Fargo, USA. He is currently working as Assistant Professor at North Dakota State University, USA. His primary research interests include tumor-targeted drug delivery, modulating the tumor microenvironment to improve outcomes of cancer therapy, and designing multifunctional, polymeric nanomaterials for drug andgene delivery. Layek has published 22 peer-reviewed articles in high impact journals and 6 book chapters for various international publishers. He has also served as a guest editor for special issues on Cell-Penetrating Peptides” and Surface-Functionalized Nanoparticles as Drug Carriers” in the International Journal of Molecular Sciences.Dr. Singh is Professor and Chair of the Department of Pharmaceutical Sciences at NDSU School of Pharmacy, and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and Fellow, Association of Biotechnology and Pharmacy. Dr. Singh's research efforts focus on the mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptide, protein, and gene), using smart polymers, nanomicelles and nanoparticles for the prevention and treatment of neurodegenerative diseases, other brain disorders, and diabetes. National Institutes of Health, US Department of Defense, PhRMA Foundation, and AFPE have funded Dr. Singh's research. Dr. Singh has published over 175 peer-reviewed papers and 350 abstracts.

Inhalt
List of contributors xv

1 Introduction to tailor-made biopolymers in drug delivery

applications

Yasir Faraz Abbasi, Parthasarathi Panda, Sanjay Arora, Buddhadev Layek

and Hriday Bera

1.1 Introduction

1.2 Biopolymers from plant and animal kingdom

1.2.1 Polysaccharides

1.2.2 Polypeptides

1.2.3 Polynucleotides

1.3 Chemical modifications of biopolymers

1.3.1 Modification approaches of polysaccharides

1.3.2 Modification approaches of polypeptides

1.4 Tailor-made biopolymers as pharmaceutical excipients

1.5 Conclusion

References

Section 1 Modified biopolymers

2 Thiolated biopolymers in drug delivery and biomedical applications

Custodiana A. Colmenarez Lobo, Mirta L. Fascio and Norma B. D'Accorso

2.1 Introduction

2.2 Thiolated biopolymers in drug delivery applications

2.3 Thiolated biopolymers in biomedical applications

2.3.1 Medicinal applications

2.3.2 Diagnosis

2.3.3 Regenerative medicine

2.4 Conclusion and future perspectives

Acknowledgments

References

3 Smart biopolymers for controlled drug delivery applications

Sanjay Arora, Riddhi Trivedi, Richard N.L. Lamptey, Bivek Chaulagain,

Buddhadev Layek and Jagdish Singh

3.1 Introduction

3.2 Different types of smart biopolymers

3.2.1 Thermosensitive smart polymers

3.2.2 pH-sensitive smart polymers

3.2.3 Light-sensitive smart polymers

3.2.4 Phase-sensitive smart polymers

3.2.5 Bioresponsive smart polymers

3.3 Conclusion

References

4 Alginate-based systems for protein and peptide delivery

Paramita Paul, Gouranga Nandi, Mohammed A. Abosheasha and

Hriday Bera

4.1 Introduction

4.2 Alginate: sources, physicochemical and biological properties

4.2.1 Sources of alginates

4.2.2 Physicochemical properties

4.2.3 Biological properties

4.3 Modifications of alginate for protein and peptide delivery

4.3.1 Covalent chemical modifications

4.3.2 Polyelectrolyte complexes

4.4 Alginate-based systems for protein and peptide delivery

4.4.1 Model protein delivery

4.4.2 Insulin delivery

4.4.3 Angiogenic factor delivery

4.4.4 Chemokine delivery

4.4.5 Bone morphogenetic protein delivery

4.5 Conclusion

References

5 Chitosan-based polyelectrolyte complexes in biomedical

applications

Buddhadev Layek, Surajit Das and Shubhajit Paul

5.1 Introduction

5.2 Polyelectrolyte complexes

5.2.1 Mechanism of polyelectrolyte complexes formation

5.2.2 Preparation of PECs and factors influencing the formation

and stability of PECs

5.3 Applications of chitosan-based polyelectrolyte complexes

5.3.1 Drug delivery

5.3.2 Gene delivery

5.3.3 Tissue engineering

5.4 Conclusion

References

6 Tailor-made cyclodextrin-based nanomaterials as drug carriers

Kazi Ali, Pradyot Roy, Arindam Maity and Pranabesh Chakraborty

6.1 Introduction

6.1.1 History

6.1.2 Source of cyclodextrins

6.1.3 Types and structure of cyclodextrins

6.1.4 Properties of cyclodextrins

6.1.5 Inclusion complex formation

6.2 Modification of cyclodextrins

6.2.1 Principle and chemistry of cyclodextrin modification

6.2.2 Characterization of modified cyclodextrins

6.3 Cyclodextrin-based nanomaterials

6.3.1 Preparation of nanomaterials from cyclodextrins and

applications

6.3.2 Different cyclodextrin-based nanomaterials

6.4 Pharmaceutical and biomedical applications of tailor-made

CD-based nanomaterials

6.5 Conclusion and future prospects

References

Further reading

Section 2 Biopolymeric conjugates/composites

7 Biopolymer_metal oxide composites in biomedical

applications

Yasir Faraz Abbasi and Hriday Bera

7.1 Introduction

7.2 Applications of biopolymer_metal oxide composites

7.2.1 Drug delivery

7.2.2 Anticancer, antioxidant, and antimicrobial activities

7.2.3 Wound healing and tissue engineering

7.2.4 Biosensors, bioimaging, and diagnostics

7.3 Conclusion

References

8 Biopolymer_drug conjugates as biomaterials

Haifei Guo, Yasir Faraz Abbasi, Hriday Bera and Mingshi Yang

8.1 Introduction

8.2 Biopolymer_drug conjugates

8.2.1 Polysaccharide-drug conjugates

8.2.2 Polypeptide_drug conjugates

8.3 Conclusion

References

9 Functionalized biopolymer_clay-based composites as drug-cargos

Hriday Bera, Motoki Ueda and Yoshihiro Ito

9.1 Introduction

9.2 Structure and properties of clays

9.3 Biopolymer_clay intercalations

9.4 Properties of biopolymer_clay-based composites as dr…