Targets of Cancer Diagnosis and Treatment

This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed.

As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.

Demonstrates how ion channels and transporters could be used as tumor markers Provides novel transport-focused approaches in anti-cancer treatment Opens up new perspectives in treatment strategies for cancer

Inhalt

Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges.- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer.- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk.- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics.- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research.- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions.- Ion Transport and Radioresistance.- Ion Transporting Proteins and Cancer: Progress and Perspectives. <p