Tef1 is a multifunctional protein of Candida albicans

This study is the first to demonstrate at the cellular level the contribution of a single surface protein to complement and immune evasion by Candida albicans. Tef1 (translation elongation factor 1) is a moonlighting protein of C. albicans. It is expressed on the cell surface, secreted, and also localized in the cytoplasm as a translation factor. Tef1 acts both as CRASP (complement regulator acquiring surface protein) directly at the site of expression and as a secreted protein away from the fungal cell surface. Tef1 binds to cells and components of the innate immune system and also influences the adaptive immune system, especially B cells. Overall, Tef1 is a multifactorial immune evasion protein of C. albicans. Its moonlighting characteristic as a surface and secreted protein allows Tef1 to modulate both the innate (complement cascade) and adaptive immune responses (B cells). Thus, Tef1 enables the persistence of C. albicans in the human organism in a variety of ways.

Autorentext

Justus Linden, born in 1987, devoted himself to researching the infection biology of Candida albicans after studying molecular biotechnology and molecular medicine in Aachen and Jena. In his dissertation, he showed that the Candida protein Tef1 influences the human B cell-mediated immune response.