The Actin Cytoskeleton

Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

Provides an up-to-date handbook on the organisation and dynamics of actin and the interaction with its companions Presents the cutting-edge view on the role of the actin cytoskeleton in signalling pathways Features the hot-topic research on the activity of toxins, viral and bacterial pathogens on the actin cytoskeleton Introduces the present knowledge on the activity of actin on chromatin organisation, transcription and RNA transport

Inhalt

Functional significance of actin isoforms.- Assembly and maintenance of myofibrils in striated muscle cells.- Myosins: Domain organisation, motor properties, physiological roles and cellular functions.- Actin filament structures in migrating vertebrate cells.- Signalling pathways controlling cellular actin organization.- Actin-based endocytosis.- ADP-ribosylation and cross-linking of actin by bacterial protein toxins.- Common themes in cytoskeletal remodeling by intracellular bacterial effectors.- Viruses that exploit actin-based motility for their replication and spread.- Multiscale view of cytoskeletal mechanoregulation of cell and tissue polarity.- Molecular control of actin dynamics in vivo insights from *Drosophila*.- From cytoskeleton to gene expression actin in the nucleus.