The Epidemiology of Adult ITP

Primary ITP is an autoimmune disease involving autoantibody- mediated platelet destruction, suboptimal platelet production, and T-cell-mediated platelet lysis. These processes cause a decreased peripheral blood platelet count, resulting in an increased susceptibility to bleeding events. Despite a marked increase in epidemiological research over the past decade, unresolved questions remain with regard to disease pathogenesis, treatment effectiveness, and co-morbid burden among adults with primary ITP. Using data from national disease registries and the medical literature, this dissertation aims (1) to characterise associations of functional, candidate SNPs in cytokine or cytokine receptor genes with primary ITP among Caucasian adults, (2) to assess the utility of autologous In-labelled platelet sequestration studies prior to possible splenectomy, (3) to evaluate the effectiveness of eradication therapy in elevating platelet counts in H. pylori-infected patients, (4) to document health-related lifestyle concerns, and (5) to characterise associations of primary ITP among adults with both arterial and venous thromboembolic events.

Autorentext

El Dr. Ameet Vilas Sarpatwari estudió epidemiología en la Universidad de Cambridge y recibió una maestría en Filosofía. en 2006 y un Ph.D. en 2010. Actualmente estudia derecho de la salud en la Facultad de Derecho de la Universidad de Maryland como académico de liderazgo mientras se desempeña como epidemiólogo principal del Registro mundial de PTI para adultos.

Klappentext

Primary ITP is an autoimmune disease involvingautoantibody-mediated platelet destruction, suboptimal plateletproduction, and T-cell-mediated platelet lysis. These processes causea decreased peripheral blood platelet count, resulting in anincreased susceptibility to bleeding events. Despite a markedincrease in epidemiological research over the past decade,unresolved questions remain with regard to disease pathogenesis, treatmenteffectiveness, and co-morbid burden among adults with primary ITP. Using data from national disease registries and the medicalliterature, this dissertation aims (1) to characterise associations offunctional, candidate SNPs in cytokine or cytokine receptor geneswith primary ITP among Caucasian adults, (2) to assess the utilityof autologous In-labelled platelet sequestration studies prior topossible splenectomy, (3) to evaluate the effectiveness oferadication therapy in elevating platelet counts in H. pylori-infectedpatients, (4) to document health-related lifestyle concerns, and (5)to characterise associations of primary ITP among adults with botharterial and venous thromboembolic events.