The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective

This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e.g., renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.

Extensively explores the mathematics of the factors that determine the biodistribution of radiopharmaceuticals Approaches the subject from a clinical point of view Presents equations primarily intended to be used conceptually, assisting in the interpretation of nuclear medicine images

Autorentext

William C. Klingensmith III, M.D. attended Cornell University in Ithaca, NY and then Cornell University's College of Medicine in New York City. He completed an internship in medicine at the University of Oregon School of Medicine in Portland, OR, a residency in radiology at the University of Colorado School of Medicine in Denver, CO, and a fellowship in nuclear medicine at the Johns Hopkins University School of Medicine in Baltimore, MD. Then he returned to the University of Colorado School of Medicine as the head of nuclear medicine for seven years. He then joined Radiology Imaging Associates, a large academically oriented private practice radiology group in Denver. After 25 years in private practice he returned to the University of Colorado School of Medicine to again head nuclear medicine.

Dr. Klingensmith has had an interest in the mathematics and biology of radiopharmaceutical localization throughout his career. During his nuclear medicine fellowship he determined the information content of first circulation time-activity curves. More recently he developed the clinically oriented equation for clearance of a radiopharmaceutical from blood into tissue, and the general algorithm for determining whether a physiologic measurement needs to be normalized for body size.

Inhalt
Part I: Introduction: General Nuclear Medicine Concepts.- Quantitative vs Visual Interpretation of Images.
Part II: Mathematics of the Biodistribution of Radiopharmaceuticals: Mathematics of the Biodistribution of Radiopharmaceuticals.- Evaluation of Clearance.- Mean Transit Time - Central Volume Principle.- Blood Flow - First Circulation Time-Activity Curves.- Parenchymal Transit Times - Convolution Analysis.- Quantitation of Function - Relative.- Quantitation of Function - Absolute.- Other Quantitative Techniques.
Part III: Overview of Part 3.- Cardiovascular System.- Central Nervous System.- Endocrine System.- Gastrointestinal System.- Genitourinary System.- Infection Imaging.- Pulmonary System.- Skeletal System.- Tumor Imaging.
Appendix A - Nuclear Medicine Studies Covered in Part 3
Appendix B - Radiopharmaceuticals and Associated Studies
Appendix C - Tables of Clearance Mechanisms