The Molecular and Cellular Biology of Wound Repair

Editing a book of this nature was a simultaneously exhilarating and frightening experience. It was exhilarating to draw from cell biologists, biochemists, and molecular biologists, as well as those dermatologists, pathologists, and pul monologists who are cell biologists at heart, to author chapters. At the same time, it was frightening to ask such busy investigators to devote their precious time to writing chapters that summarize not just their own endeavors but their entire area of expertise. However, the authors assuaged our fears by enthusi astically accepting the proposal to write on specific topics despite the time burden, and to update and willingly accept our editorial comments. In the editors' view, the authors have captured the important scientific data in their respective fields, have organized the data into an understandable outline, and have applied the information to elucidating wound repair processes. The explosion of new, important discoveries in the field of wound repair and related areas as our book was developing has been very unsettling. This observation predicts obsolescence. In response to this possibility, the authors and the editors have attempted to build fundamental concepts upon existing data. Hopefully, these concepts will help provoke further experimentation to unravel the complex, interwoven processes of wound repair. The book has been organized into three parts: Inflammation, Granulation Tissue Formation, and Extracellular Matrix Production and Remodeling.

Inhalt
I. Inflammation.- 1 Overview and General Considerations of Wound Repair.- 2 Platelets and Response to Injury.- 3 Potential Functions of the Clotting System in Wound Repair.- 4 Endothelial Cell Regulation of Coagulation.- 5 Factors That Affect Vessel Reactivity and Leukocyte Emigration.- 6 Neutrophil Emigration, Activation, and Tissue Damage.- 7 Resolution of Inflammation.- 8 The Multiple Roles of Macrophages in Wound Healing.- II. Granulation Tissue Formation.- 9 The Role of Growth Factors in Tissue Repair I: Platelet-Derived Growth Factor.- 10 The Role of Growth Factors in Tissue Repair II: Epidermal Growth Factor.- 11 The Role of Growth Factors in Tissue Repair III: Fibroblast Growth Factor.- 12 The Role of Growth Factors in Tissue Repair IV: Type ?-Transforming Growth Factor and Stimulation of Fibrosis.- 13 Mechanisms of Parenchymal Cell Migration into Wounds.- 14 Re-epithelialization.- 15 Angiogenesis.- 16 The Role of Cell-Cell Interaction in the Regulation of Endothelial Cell Growth.- 17 The Biology of the Myofibroblast Relationship to Wound Contraction and Fibrocontractive Diseases.- III. Extracellular Matrix Production and Remodeling.- 18 Fibronectin: A Primitive Matrix.- 19 Proteoglycans and Wound Repair.- 20 Collagen in Dermal Wound Repair.- 21 Role of Degradative Enzymes in Wound Healing.- 22 Basement Membranes.- 23 Re-formation of the EpidermalDermal Junction during Wound Healing.