The Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. The major morbidity relates to patients' symptomatic cytopenias.MDS was previously named as preleukemia or smoldering leukemia as the lack of terminal cells in MDS and because about 25% of all cases progresses into acute myeloid leukemia.According to various reports the annual incidence of MDS ranges widely from 2-12 per 100.000, increasing to 30-50 cases per 100.000 among persons aged 70 or older. It is believed that the true incidence of MDS have been underestimated however it seems to be comparable to that for multiple myeloma and chronic lymphocytic leukemia. In the past decade much progress had been made; we know more on the disease pathology, there is more emphasis on the care and more targeted therapy had been invested. Athors provide updated knowledge in this book on all clinically important aspects of the disease. Hot topics of our days are discussed in chapters by outstanding and well known scientists from all over the world. We would offer this product both for medical students and postgraduates as well as for all who are interested in this very exciting and fast progressing field of hematology.With this work authors should call attention on the disease for decision makers in healt care systems as well.

Updated patient stratification for the different therapeutical modalities Updated disease classification Update of the available therapies Includes supplementary material: sn.pub/extras

Inhalt

1. PREFACE.- 2. The history of the Myelodysplastic Syndromes.- 3. Susceptibility to MDS: DNA repair and detoxification genes.- 4. Myelodysplastic syndromes/neoplasms: Morphological and Immunohistochemical features and standard evaluation.- 5. Diagnostic Criteria and Classification of Myelodysplastic Syndromes.- 6. Cytogenetics of MDS.- 7. Molecular changes in myelodysplastic syndrome.- 8. Prognostic Scoring in MDS.- 9. Flow Cytometry in Myelodysplastic Syndromes.- 10. MDS as an Autoimmune Process.- 11. The Myelodysplastic Overlap Syndromes.- 12. Iron and copper Metabolismin the Myelodysplastic Syndromes.- 13. Pathogenesis and Management of Iron Overload in MDS.- 14. Cytokines in MDS. Abnormalities and treatment.- 15. Therapeutic Modalities and new molecular targets in MDS.- 16. Haematopoietic Stem Cell Transplantation in MDS for Adults.- 17. JMML and Myelodysplastic Syndrome in children.