The New Angiotherapy

An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.

Includes supplementary material: sn.pub/extras

Klappentext
Angiogenesis, the development of new blood vessels from an existing vascular bed, is an essential feature in many pathological conditions, including cancer, atherosclerosis, rheumatoid arthritis, and diabetic neuropathy. Inadequate regulation of angiogenesis can often lead to chronic pressure ulcers, duodenal ulcers, and myocardial infarction. In The New Angiotherapy, an international team of experts critically review the recent progress in both basic and applied research on angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel angiotherapeutic targets and their use in the clinic. Details of fundamental concepts in angiogenesis physiology and pathophysiology are provided, and the potential of angiotherapy in the management of angiogenic disease is evaluated, highlighting some of the angiogenic and antiangiogenic agents both in development and in clinical trials. The future prospects of receptor antagonists, enzyme inhibitors, and vascular targeted approaches, especially gene therapy in the development of angiotherapy, are also covered.
Authoritative and cutting-edge, The New Angiotherapy illuminates our understanding of the central role of human angiogenesis, as well as the novel therapeutic approaches now made possible by our ability to control vascular development.

Inhalt
1 Vasculogenesis and Angiogenesis.- 2 Angiogenesis-Regulating Cytokines.- 3 The Angiopoietins.- 4 Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins.- 5 Integrin Receptors and the Regulation of Angiogenesis.- 6 Vasoactive Peptides in Angiogenesis.- 7 Angiogenesis in Wound Healing and Surgery.- 8 Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction.- 9 Rheumatoid Arthritis: A Target for Anti-Angiogenic Therapy?.- 10 Diagnostic and Prognostic Significance of Tumor Angiogenesis.- 11 Hyaluronan Oligosaccharides Promote Wound Repair: Its Size-Dependent Regulation of Angiogenesis.- 12 Role of Thymic Peptides in Wound Healing.- 13 Angiogenesis and Growth Factors in Ulcer Healing.- 14 Angiogenesis in Skeletal and Cardiac Muscle: Role of Mechanical Factors.- 15 Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease.- 16 Therapeutic Angiogenesis for the Heart.- 17 Contact-Guided Angiogenesis and Tissue Engineering.- 18 Inhibitors of Matrix Metalloproteinases.- 19 Control of Angiogenesis by Microbial Products.- 20 Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans: Implications for the Development of Angiostatic Compounds.- 21 2-Methoxyestradiol: A Novel Endogenous Chemotherapeutic and Anti-Angiogenic Agent.- 22 Receptor Tyrosine Kinases in Angiogenesis.- 23 Targeting Gene Therapy to the Tumor Vasculature.- 24 Antibody Targeting of Tumor Vasculature.- 25 Endothelial Monocyte-Activating Polypeptide II: A Novel Injury Signal?.- 26 CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells.- 27 Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases.- 28 Design of Clinical Trials for Anti-Angiogenics.- 29 Angiogeneis Therapies: Concepts, Clinical Trials, and Considerations for New Drug Development.- 30 Angiostatin and Endostatin: Recent Advances in Their Biology, Pharmacokinetics, and Potential Clinical Applications.