The New Paradigm of Immunity to Tuberculosis

This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It explores a novel approach to designing a new tuberculosis vaccine.

Will offer a new understanding of immunity to tuberculosis Explore a novel approach to designing a new tuberculosis vaccine Cover the latest advances in tuberculosis research of the past decade Includes supplementary material: sn.pub/extras

Inhalt
Epidemiology of tuberculosis immunology.- Host pathogen specificity in tuberculosis.- Genetic determinants of susceptibility to mycobacterial infections.- Evolution of mycobacterium tuberculosis.- Mycobacterium tuberculosis genes involved in regulation of host cell death.- Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis.- Cytokines in the balance of protection and pathology during mycobactyerial infections.- Antigen-specific CD8+ T cells and protective immunity to tuberculosis.- Foxp3+ regulatory T cells in tuberculosis.- CD1a, CD1b, and CD1c in immunity against mycobacteria.- CD1d and natural killer T cells in immunity to mycobacterium tuberculosis.- The role of B cells and humoral immunity in mycobacterium tuberculosis infection.- Looking within the zebrafish to understand the tuberculosis granuloma.- Immunization strategies against pulmonary tuberculosis: Considerations of T cell geography.