The Pathobiology of Breast Cancer

This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genomic testing are also explored, which will provide a window to the future progress of cancer care.

Discusses the pathobiology of all invasive breast cancer types Explores the role of metastasis, stem cells, and drug resistance Written by well-renowned expert in the field of breast cancer Includes supplementary material: sn.pub/extras

Autorentext
Jose Russo, MD is Professor and Senior Member of the FCCC. He is Director of the Irma H. Russo, MD-Breast Cancer Research Laboratory and Director of the Breast Cancer and The Environment Research Center at the Fox Chase Cancer Center-Temple Health. Dr, Russo is also Adjunct Professor of Pathology and Cell Biology at Jefferson Medical School and Professor of Biochemistry at Temple Medical School in Philadelphia, Pennsylvania. Dr Jose Russo has authored more than 400 publications; 13 books and is member of several editorial boards of scientific journals. He has received numerous research awards from the National Cancer Institute of the National Institute of Health (NIH) of the United States, from the American Cancer Society and the Department of Defense for his original research in breast cancer. For the last 35 years he has been an active member of the NIH peer review system and has served as a special reviewer for the American Cancer Society, National Science Foundation, Department of Defense and Veteran Affairs. Dr. Russo has trained 55 Ph.D. and M.D. investigators in cancer research. The interest of Dr. Russo has a broad base, but with a focused goal; 1) to understand the mechanisms that control cancer metastasis and 2) to develop strategies for breast cancer prevention.

Inhalt
The windows of susceptibility to breast cancer.- The so called pre-neoplastic lesions and carcinoma in situ.- The pathobiology of the breast cancer Invasive process.-The invasive Breast Cancer Types.- The Molecular Basis of Breast Cancer Subtypes.- Stem cells in breast cancer.-The mechanisms of Breast Cancer metastasis.- How to build up adequate Prognostic markers in the Molecular biology context of breast cancer.- Preclincial models for studying brest cancer.-Biological Basis of Breast Cancer Prevention.