the role of cytokines on synaptic plasticity in the dentate gyrus

Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer s disease. Tumour necrosis factor- (TNF- ) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF- and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF- and IL-18 can impair LTP in the dentate gyrus.

Autorentext

Derval Cumiskey se graduó con una licenciatura en farmacología en el University College de Dublín en 2002 antes de completar un doctorado en neurociencia en el University College de Dublín.