The Role of Interim FDG-PET/CT in Pediatric Hodgkin's Lymphoma

Purpose of the study: was to estimate the value of early assessment of response in pediatric Hodgkin lymphoma (PHL) patients using FDG-PET/CT. Methods: prospective analysis of 195 patients (CCHE) with pathologically proven untreated PHL, they underwent18 FDG PET/CT early after 2 cycles of chemotherapy (PET 2). Analysis of PET 2 was done according to the Deauville score. Results: Follow-up for mean period of 2.9 years. Visual assessment of PET 2 was found to be significantly correlated with the estimate for OS and PFS was 83.3% and 68.8 respectively in the PET-positive (PET +ve) group compared with 97.3% and 92.6 % respectively in the PET-negative (PET -ve) group (p-value 0.0001 and 0.0001). Conclusion: Early assessment of FDG-PET/CT after 2 cycles of ABVD in PHL shows potential value in prediction of OS and PFS in advanced stages (intermediate and high risk patients). Key words: FDG-PET/CT, pediatric HL, prognosis.

Autorentext

Doutoramento em NM, Universidade do Cairo, Egipto 1979. Professor de NM, Universidade do Cairo 1990-até à data. Chefe do projeto AFRA NM no Egipto 2003-2020. Diretor da Sociedade Egípcia de Especialistas em NM 1998 - até à data. Diretor da revista egípcia de NM 2008-até agora. Número de apresentações internacionais 44. Número de apresentações nacionais 102.