The Role of Platelets in Blood-Biomaterial Interactions

Medicine and engineering work together towards solutions for biomedical problems. The interactions of blood elements with artificial materials (bags, tubes, artificial organs, etc.) require many disciplines for its understanding. Thus the effort presented in this book is the culmination of a genuine discussion on the problems arising in blood banks, in hospitals, in biomaterials development, in experimental hemocompatibility testing when platelets interact with biomaterials. Hematologists, chemists, biologists and engineers have tried to put their own point of view and to understand the point of view of the other disciplines. The main themes that are presented in the discussion are: Platelet collection, storage and transfusion; Hemostasis and anticoagulation; Platelet and biomaterials, extracorporeal circulation and implanted materials; Hemorheological parameters; Modulation of platelet function; Biological tests for evaluating platelet--biomaterial interactions. £/LIST£

Inhalt
One: Molecular Basis for Platelet Interactions with Biomaterials.- 1. Ultrastructure of platelets and platelet-surface interactions.- 2. Structure and function of platelet membrane glycoproteins.- 3. Platelet immunology: allo-antigens, transfusion.- 4. Pharmacology of platelets.- Two: Platelet Surface Interactions Cellular and Rheological Aspects.- 5. The role of hemodynamics on the cellular responses.- 6. Platelet adhesion to surfaces.- 7. Role of thrombin in platelet-biomaterial interactions.- 8. Polymorphonuclear leukocytes modulate platelet function.- Three: Discussion Chapters.- 9. Platelet collection, storage and transfusion.- 10. Platelet: haemostasis and anticoagulation.- 11. Platelet and biomaterials, extracorporeal circulation and implanted materials.- 12. Hemorheological parameters.- 13. Modulation of platelet functions.- 14. Biological tests for evaluating platelet biomaterial interaction.- Index of names.- Index of subjects.