The Role of PYY in Regulating Appetite

Obesity is the most prevalent nutritional problem in
the industrial countries, which is going to be the
futures predispose in the development of diseases
like type 2 diabetes, osteoarthritis and
cardiovascular diseases. It is essential to
understand the physiology of normal appetite
regulation in order to design an effective drug to
treat the increase of obesity.
The investigated peptide, PYY, exists in two forms,
PYY1-36 and PYY3-36. Today there are 5 different
receptors known where both forms bind to, but with
different affinity. PYY3-36 has its highest affinity
to the so called Y2 receptor. Both peptides play a
crucial role in regulating appetite. PYY3-36
inhibits feeding in rodents, non-human primates and
humans. The hypothalamus and brain stem are thought
to be the brain areas responsible for regulating
appetite.
The goal of this work was to determine the
activation of neurons in forebrain and hindbrain
sites containing Y2 receptors and linked to control
of food intake, when injecting PYY1-36 and PYY3-36.
Wild type-like mice and Y2ko mice received a dose of
PYY1-36 and PYY3-36 and the c-Fos expressing neurons
were determined.

Autorentext
Isabella Kanzler, Dipl. - Ing. (FH): Studies in medical and pharmaceutical Biotechnology at the IMC Krems University of Applied Sciences. Scientific associate at the IMCAR, University Hospital Aachen.

Klappentext
Obesity is the most prevalent nutritional problem in the industrial countries, which is going to be the futures predispose in the development of diseases like type 2 diabetes, osteoarthritis and cardiovascular diseases. It is essential to understand the physiology of normal appetite regulation in order to design an effective drug to treat the increase of obesity. The investigated peptide, PYY, exists in two forms, PYY1-36 and PYY3-36. Today there are 5 different receptors known where both forms bind to, but with different affinity. PYY3-36 has its highest affinity to the so called Y2 receptor. Both peptides play a crucial role in regulating appetite. PYY3-36 inhibits feeding in rodents, non-human primates and humans. The hypothalamus and brain stem are thought to be the brain areas responsible for regulating appetite. The goal of this work was to determine the activation of neurons in forebrain and hindbrain sites containing Y2 receptors and linked to control of food intake, when injecting PYY1-36 and PYY3-36. Wild type-like mice and Y2ko mice received a dose of PYY1-36 and PYY3-36 and the c-Fos expressing neurons were determined.