The UNC-53-mediated Interactome

This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.

In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. Neuron Navigators (NAV) are also involved in nervous system development

The book presents C. elegans as model organism for the development of the nervous system translation Discusses various disorders that are associated with improper wiring of the nervous system Gives an overview on various interactomes involved in DV and AP guidance, their mechanism of action, subcellular localization and functional role Includes supplementary material: sn.pub/extras

Autorentext
Dr. Girdhar Pandey serves as Associate Professor for the Department of Plant Molecular Biology at the University of Delhi South Campus. Dr. Pandey has published and contributed to widely praised books on plant genetics and genomics, including GTPases: Versatile Regulators of Signal Transduction in Plants (Springer, 2015), Abiotic Stress Adaptation in Plants: Physiological, Molecular and Genomic Foundation (Springer, 2010), and Biotechnology in Sustainable Biodiversity and Food Security (Science Publishers, Inc., 2003).

Inhalt
Introduction.- Guidance molecules required for growth cone migrations of cells and axons.- Mechanism for asymmetric localization of guidance receptors during growth cone migration and outgrowth.- Signaling pathways downstream of the guidance cues and receptors.- Functional characterization of adaptor protein UNC-53 during axon outgrowth and cell migration.