Thiocillin I

Over the past half century, the absolute configuration of thiopeptide antibiotics such as Thiocillin I has baffled chemists until the first correct synthesis of Micrococcin P1 in 2009. At this point we had to answer two questions - first, does the absolute configuration hold true for its natural analogues? Second, can we design a more efficient synthesis of the tri-substituted pyridine core? The current synthesis sheds light on these problems especially for medicinal chemists who wish to explore the SAR for the purposes of drug development.

Autorentext

Virender Singh Aulakh, M.Sc.: Studied chemistry at the University of British Columbia. Medicinal chemist with Novartis Institutes of Biomedical Research (Infectious Diseases), Cambridge, Massachusetts, USA