Thrombin

Thrombin and thrombin receptors are involved in many physiological processes and can contribute to a variety of disease states. This book will stimulate interest in new targets of drug development and increase our understanding of the multiplicity of thrombin.

In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields.

This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Stimulate interest in new targets of drug development and increase our present day understanding of the multiplicity of roles endowed to thrombin through the evolutionary process

Klappentext

It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets."

Inhalt
Thrombin: Structure, Functions, and Regulation.- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation.- Regulation of Thrombin Receptor Signaling.- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology.- The Role of Thrombin in Vascular Development.- The Role of Thrombin in Angiogenesis.- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair.- The Role of Thrombin and Thrombin Receptors in the Brain.- The Role of Thrombin in Tumor Biology.- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation.- Anti-thrombotic Therapy in Cancer Patients.- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application.- Novel Anticoagulant Therapy: Principle and Practice.