Thyroid Cancer

Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.

Comprehensive, definitive, gold-standard text in the field Expanded, with approximately 30 new chapters and fully updated references Written by a panel of world-class clinicians reviewing all aspects of thyroid cancer from pathogenesis to prognosis, including management and treatment Includes supplementary material: sn.pub/extras

Autorentext
Leonard Wartofsky, MD, MACP

Department of Medicine

Washington Hospital Center

Washington, DC, USA

Douglas Van Nostrand, MD, FACP, FACNM

Nuclear Medicine

Washington Hospital Center

Washington, DC, USA

Inhalt
PART I. General Considerations I: THYROID CANCER.- 1 Anatomy and Physiology of the thyroid gland: Clinical Correlates to Thyroid Cancer.- 2 Epidemiology of Thyroid Cancer.- 3 Molecular Pathogenesis of Thyroid Cancer & Oncogenes in Thyroid Cancer.- 4 Molecular Aspects of Thyroid Cancer in Children.- 5 The Role of Genetics in the Development of Familial Non-Medullary Thyroid Cancer.- 6 Apoptosis in Thyroid Cancer.- 7 Radiation-Induced Thyroid Cancer.- 8 Classification of Thyroid Malignancies.- 9 Staging of Thyroid Cancer.- 10 Recombinant human Thyrotropin (Thyrogen®).- PART II. GENERAL CONSIDERATIONS II: NUCLEAR MEDICINE.- 11 Radioiodine Whole Body Imaging.- 12 Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy.- 13 False-Positive Radioiodine-131 scans in Thyroid Cancer.- 14 The Utility of SPECT-CT in Differentiated Thyroid Cancer.- 15 Radioiodine scintigraphy with SPECT/CT: an important diagnostic tool for staging and risk stratification.- 16 Stunning by 131I scanning: Untoward Effect of 131I Thyroid Imaging Prior to Radioablation Therapy.- 17 Stunning is Not a Problem.- 18 Stunning: Does it Exist? A Commentary.- 19 To Perform or Not to Perform Radioiodine Scans Prior to 131I Remnant Ablation?.- PART III. THE THYROID NODULE.- 20 The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management.- 21 Fine-Needle Aspiration.- 22 Diagnostic and Prognostic Molecular Markers in Thyroid Cancer.- 23 Ultrasonic Imaging of the Thyroid Gland.- 24 Radionuclide Imaging of Thyroid Nodules.- 25 18F Fluoro-deoxyglucose PET and Thyroid Nodules.- 26 Thyroid Nodules and Cancer Risk: Surgical Management.- 27 Thyroid Nodules in Children and Cancer Risk.- 28 Management of the Thyroid Nodule: A Comparison Of Published International Guidelines.- PART IV. WELL-DIFFERENTIATED THYROID CANCER A: PAPILLARY CARCINOMA: PRESENTATION.- 29 Papillary Carcinoma: Clinical Aspects.- 30 Papillary Microcarcinoma.- 31 Surgical Approach to Papillary Thyroid Cancer.- 32 Papillary Carcinoma: Cytology and Pathology.- B. INITIAL MANAGEMENT.- 33 Remnant Ablation, Adjuvant Treatment and Treatment of Locoregional Metastases with 131I.- 34 Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin.- C. SURVEILLANCE.- 35 Follow-up Strategy in Papillary Thyroid Cancer.- 36 Thyroid Hormone Therapy and Thyrotropin Suppression.- 37 Thyroglobulin for Differentiated Thyroid Cancer: Measurement and Interferences.- 38 Thyroglobulin Antibodies and Their Measurement.- 39 Diagnosis of Recurrent Thyroid Cancer in Patients with Anti-Thyroglobulin Antibodies.- 40 Ultrasound of the neck lymph nodes.- 41 Surveillance Radioiodine Whole Body Scans.- 42 Radionuclide Imaging and Treatment of Children with Thyroid Cancer.- 43 Positron Emission Tomography-/Computed Tomography (PET-CT and PET) in Well-Differentiated Thyroid Cancer.- 44 Alternative Thyroid Imaging.- 45 MR and CT Imaging of Thyroid Cancer.- 46 Thyroglobulin in Lymph Node Aspirate.- 47 Management of the Patientswith Negative Radioiodine Scan and Elevated Serum Thyroglobulin.- 48 Prognosis in Papillary Thyroid Cancer.- 49 Surgical Management of Lymph Node Metastases.- 50 Utility of Second Surgery for Lymph Node Metastases.- 51 Papillary Cancer Special Aspects in Children.- 52 Special Presentations of Thyroid Cancer in Thyrotoxicosis, Renal Failure, and Struma Ovarii.- 53 Thyroglossal Duct Carcinoma.- 54 Thyroid Cancer in Pregnancy.- D. TREATMENT.- 55 Radiation and Radioactivity.- 56 131I Treatment of Distant Metastases.- 57 Treatment of Metastatic Thyroid Cancer with Radioiodine following preparation by Recombinant Human Thyrotopin.- 58 Dosimetrically-Determined Prescribed Activity of 131I for the Treatment of Metastatic Differentiated Thyroid Carcinoma.- 59 Simplified Methods of Dosimetry.- 60 Radioiodine Dosimetry with Recombinant human Thyrotropin.- 61 The Use of Lithium as an Adjuvant to Radioiodine In the Treatment of Thyroid Cancer.- 62 Side Effects of 131I for Therapy of DifferentiatedThyroid Carcinoma.- 63 Radiation Therapy in Papillary Carcinoma.- 64 Chemotherapy of Thyroid Cancer: General Principles.- 65 Bone Metastases from Differentiated Thyroid Carcinoma.- 66 A Summary of Rare Sites of Metastasis Secondary to Differentiated Thyroid Cancer.- 67 Adjunctive Local Approaches to Thyroid Nodules and Metastatic Thyroid Cancer.- 68 Radioiodine-Refractory Thyroid Cancer: Restoring Response to Radioiodine Therapy.- 69 Alternative and Complementary Treatment of Thyroid Disorders.- PART V. WELL-DIFFERENTIATED THYROID CANCER FOLLICULAR CARCINOMA.- 70 Follicular Thyroid Carcinoma.- 71 Surgical Management of Follicular Cancer.- 72 Pathology of Follicular Cancer.- 73 Hürthle Cell Carcinoma.- 74 Follow-Up Strategy in Follicular Thyroid Cancer.- 75 Radionuclide Imaging and 131I Therapy in Follicular Thyroid Carcinoma.- 76 PET/CT in Follicular Cancer Including Hürthle Cell Cancer.- 77 Follicular Thyroid Cancer: Special Aspects in Children and Adolescents.- 78 External Radiation Therapy of Follicular Carcinoma.- 79 Determinants of Prognosis of Follicular Thyroid Carcinoma.- PART VI. VARIANTS OF THYROID CANCER.- 80 Aggressive Variants of Papillary Thyroid Carcinoma and Poorly Differentiated Carcinoma.- 81 Miscellaneous and Unusual Tumors of the Thyroid Gland.- 82 Pathology of Miscellaneous and Unusual Tumors of the Thyroid Gland.- PART VII. UNDIFFERENTIATED TUMORS: MEDULLARY THYROID CARCINOMA.- 83 Clinical Aspects of Medullary Thy…