Transfusion-related acute lung injury (TRALI)

Transfusion-related acute pulmonary edema (TRALI) is a transfusion-related incident whose etiology and pathophysiology are still debated, suggesting immunological or non-immunological mechanisms, following leukocyte activation by biological response modifiers (BRMs) supplied by transfused labile blood products (LBP).Using 4 cases of TRALI reported to the haemovigilance unit of the Sfax CRTS, we discuss epidemiology, pathophysiology, positive and differential diagnosis, management and primary and secondary prevention.

Autorentext

Dr Nour Louati, MD-PhD, profesor nadzwyczajny medycyny, hematobiologia, jednostka cytometrii przep ywowej, laboratorium hematobiologiczne, Regionalne Centrum Transfuzji Krwi w Sfax, Uniwersytet w Sfax, Wydziä Medycyny, Sfax, Tunezja.