Translational Advances in Gynecologic Cancers

Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included.

Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus.

Autorentext
Dr. Michael Birrer is a Professor of Medicine at Harvard Medical School, the Director of Medical Gynecologic Oncology, Gynecologic Oncology Research Program, and the Gellete Center for Gynecologic Oncology at Massachusetts General Hospital (MGH) in Boston, Massachusetts. He is also a practicing physician at MGH. The Birrer laboratory has had a long-term interest in characterizing the molecular origins of gynecologic cancers. This interest includes the identification and characterization of mutations in oncogenes and tumor suppressor genes within cancers of the ovary, endometrial and cervix. In addition, they have extensively characterized the differential gene expression in these tumors. The role of these genes in the development of these cancers has been tested using in vitro and in vivo model systems. The laboratory is focused on using the genomic events characterized in these cancers to produce translational science endeavors, which will result in clinically important discoveries. These genomic abnormalities form the basis for early detection assays, prevention strategies, and novel therapeutic approaches. Dr. Birrer's laboratory focuses on bench-to-bedside-and-back-again approaches to produce clinically relevant strategies to better manage women with these cancers.MD, Department of Medicine, Division of Hematology-Oncology, Massachusetts General Hospital, Boston, MA, USA

Klappentext
Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

Inhalt

Part I: Ovarian Cancer 1. Origins of Epithelial Ovarian Cancer 2. Ovarian Cancer Genomics 3. Epigenetics 4. Timing of Cytoreductive Surgery in the Treatment of Advanced Epithelial Ovarian Carcinoma 5. Angiogenesis 6. Homologous Recombination and BRCA Genes in Ovarian Cancer: Clinical Perspective of Novel Therapeutics 7. Molecular Basis of PARP Inhibition and Future Opportunities in Ovarian Cancer Therapy 8. Ovarian Cancer: New Targets and Future Directions 9. Novel Chemotherapy Tools: Intraperitoneal Therapy, Dose-Dense Therapy 10. Updates on Rare Epithelial Ovarian Carcinoma

Part II: Endometrial Cancer 11. Endometrial Cancer Genomics 12. Sentinel Lymph Node Mapping Procedures in Endometrial Cancer 13. The Role of Radiation in Uterine Cancer

Part III: Cervical Cancer 14. Novel Therapies for Advanced Cervical Cancer

Part IV: Vulvar Cancer 15. New Therapies in Vulvar Cancer

Part V: Fertility and Cancer 16. Fertility and Cancer: Fertility Preservation and Fertility Sparing Surgery