Translational Approaches to Autism Spectrum Disorder

This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any, proven therapies for the majority of the disorders. Among the topic addressed are neural plasticity, neuroimmunology, neuroinflammation, neuroimaging, and appropriate animal and genetic models.

Offers a comprehensive view of translational research on autism spectrum disorder Provides guidance to relevant research methods for work with animal models Combines experimental and clinical perspectives to address potential therapy options Includes supplementary material: sn.pub/extras

Autorentext

Maria de los Angeles Robinson-Agramonte is the Head of Project Biomolecular Markers and Neurointervention in Autism Spectrum Disorders in the division of Science and Technology, CIREN, International Center for Neurological Restoration. She graduated from the Medical University of Santiago de Cuba with an MD, and went on to receive her Ph. D. in Immunology from the Medical School at Havana University. Dr. Robinson-Agramonte has since worked on basic and clinical research projects on Neurodegenerative diseases like Alzheimer's disease, Demyelinating diseases, and Neurodevelopment diseases with a focus on ASD. She has published more than 35 publications and five book chapters. She has won various National Annual Prizes, including the Cuban Science Academy award and the Cuban Society of Immunology's Clinical Research Award.

Inhalt

Autism: what is it.- Epidemiology of Autism Spectrum Disorders.- The Genetic Basis of Autism Spectrum Disorder.- Autism spectrum disorder: A clinical neurophysiology approach I.- Autism spectrum disorder: A clinical neurophysiology approach II.- Neuroimages in Autism.- Autism, development and neural plasticity.- Neuroinflammation in animal models of autism.- Understanding of neuroimmunology in autism spectrum disorder.- Antibody mediating autoimmune reaction in autism spectrum disorder.- Current therapies.