Trends in mRNA Vaccine Research

The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines
In 'Trends in mRNA Vaccine Research', a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines. They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, Plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines.
Volume highlights include:

• A historical overview of mRNA vaccine development
• Immune responses to modified or unmodified mRNA vaccines
• A description of the different mRNA vaccine platforms

• Latest data on current mRNA vaccine developments against infectious diseases and cancer
  Perfect for medicinal chemists, immunologists, and epidemiologists, 'Trends in mRNA Vaccine Research' will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.

  Autorentext

  Gabor Tamas Szabo, MD, PhD, is an Associate Director at BioNTech SE. His work is focuses on mRNA technology optimization and applications.

  Norbert Pardi, PhD, is an Assistant Professor at the University of Pennsylvania, USA. His research is focused on the development of mRNA-based therapeutics with a focus on vaccines.

  Inhalt
  PART I: HOW mRNA VACCINES WORK
  A Historical Overview on mRNA Vaccine Development
  Immune Responses to mRNA Vaccines
  Modified or Unmodified mRNA Vaccines? - The Biochemistry of Pseudouridine in mRNA Vaccines
  Self-replicating RNA Viruses for Vaccine Development
  Circular RNA Therapeutics and Vaccines
  GMP and Up-scaling of mRNA Vaccine Production
  mRNA Vaccination for Induction of Immune Tolerance Against Autoimmune Disease

  PART II: RECENT PROGRESS IN VACCINE RESEARCH AND DEVELOPMENT
  Approved mRNA Vaccines Against SARS-CoV-2
  mRNA Vaccines for HIV-1
  mRNA Vaccines Against Tick-borne Diseases
  mRNA Vaccines for Malaria and Other Parasitic Pathogens
  mRNA Vaccines Against Mycobacterium tuberculosis
  Cancer Vaccines Based on mRNA: Hype or Hope?