Trends in Stem Cell Proliferation and Cancer Research

This book details the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology.

State-of-the art information on proliferation mechanisms and cancer research including cancer stem cells, written by leaders of the field around the world Comprehensive introduction with excellent figure material The book is written in a way for addressing researchers from various disciplines Audience includes university libraries, graduate students as well as researchers on post-doctoral and professor level, physicians interesting in novel approaches of therapy, academics and scientists of pharmaceutical industry, academics from related areas (biomedicine, pharmacy, chemistry), graduate student classes at the Universities of São Paulo and Belo Horizonte, international conferences and workshops (Cell Biology, medicine among others)

Inhalt

Part I Molecular bases for stem and cancer cells proliferation.- An introduction to proliferation and migration of stem cells and cancer.- the role of cell adhesions, cell junctions and extracellular matrix in normal development and carcinogenesis.- The embryonic rest hypothesis of cancer development: 150 years later.- Are calcium channels more important than calcium influx for cell proliferation ?- Role of calcium signaling in stem cells and cancer cells proliferation.- |Formation and function of lipid droplets in inflammation and cancer.- The role of sphingolipids in modulating pluripotency of stem cells.- Part II Signaling pathways to cancer cells fate.- Signaling pathways of cbl-b and its role on peripheral t cell tolerance.- Bh3-only proteins in cancer and apoptosis.- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis.- Signalling pathways of -catenin/jnk on carcinogenesis.- The regulation of the jnk cascade and programmed cell death by nf-b: mechanisms and functions.- Part III Uncontrolled physiology process guiding to cancer cells.- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors.- Autophagy, cell death, and cancer.- the duality of stem cells double edged sword in tumour evolution and treatment.- Glioblastoma stem cells and implications for chemoresistance.- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions.- Tumor-associated neutrophils (tans).- Microrna control of apoptotic programs in cancer.- Part IV Therapeutic strategies for anticancer treatment.- Markers of cancer stem cells and their functions.- Cancer cell dormancy: potential therapeutic targets to eradicate cancer cells within the niche.- Modulating apoptosis in cancer therapy with ultrasound and high intensity nanosecond electric pulses.- Targeting cell cycle for anticancer treatment andneuroprotection.