Trichostatin A
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Details
High Quality Content by WIKIPEDIA articles! Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some uses as an anti-cancer drug.
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GarantieWeitere Informationen
- Allgemeine Informationen
- GTIN 09786131016820
- Editor Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
- Genre Chemie
- Größe H6mm x B220mm x T150mm
- EAN 9786131016820
- Format Fachbuch
- Titel Trichostatin A
- Gewicht 168g
- Herausgeber Betascript Publishing
- Anzahl Seiten 100
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