Tumor Microenvironment

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling.

Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins Part B updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Provides a comprehensive overview of the state-of-the-art research on the role of interleukins in the tumor microenvironment Illustrates how various interleukins act on cells within the tumor to affect cancer cell proliferation and survival Addresses the effects of tumor-related interleukins in anti-cancer therapy development

Autorentext

Alexander Birbrair received his Bachelor's Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette's laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Inhalt

Interleukin-6 function and targeting in prostate cancer.- IL-7 signaling in the tumor microenvironment.- IL-10 Signaling in the Tumor Microenvironment of Epithelial Ovarian Cancer.- Targeted delivery of IL-12 adjuvants immunotherapy by oncolytic viruses.- IL-22 signaling in the tumor microenvironment.- IL-23 and the Tumor Microenvironment.- Interleukin (IL)-24: Reconfiguring the tumor microenvironment for eliciting antitumor response.- Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment.- Index.