Tumor Microenvironment

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists' focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research.
All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Provides the latest research on both extracellular matrix and cancer biology topics Covers the different roles keratan sulphate, hyaluronan, fibronectin, and matrix metalloproteinases have in the tumor microenvironment Illustrates the influence perlecan has in the tumor microencironment

Autorentext

Alexander Birbrair received his Bachelor's Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette's laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA).

Inhalt

The tumor microenvironment: focus on extracellular matrix.- Keratan Sulphate in the Tumour Environment.- Hyaluronan in the tumor microenvironment.- Fibronectin in the tumor microenvironment.- Matrix metalloproteinases role in tumor microenvironment.- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment.- Heparan sulfate in the tumor microenvironment.- The role of Glypican-1 in the tumour microenvironment.- Index.