Tumor Therapy Monitoring with Diffuse Optical Spectroscopies

The diffuse optical technique using Near-Infrared
(NIR) light provides a promising
means for non-invasive imaging and clinical
diagnosis of deep tissues. This book focuses on a
multi-modal diffuse optical technique combining two
qualitatively different methodologies: Diffuse
Reflectance Spectroscopy (DRS) and Diffuse
Correlation Spectroscopy (DCS). This approach
permits real-time, non-invasive and simultaneous
quantification of tissue hemoglobin concentration,
blood oxygen saturation and blood flow. This book
outlines the basic principles, mathematical modeling
and then practical instrumentation that enable
monitoring of tumor responses to therapies in
preclinical and clinical contexts. Targeted audience
of this book is scientists who are interested in
basic principles of diffuse optics and its
applications to translational research and medical
doctors who are interested in practical tools for
therapy monitoring in clinics.

Autorentext
Dr. Ulas Sunar earned his Ph.D. in Physics from University of Pennsylvania, Philadelphia in 2006. He worked as a postdoctoral scholar in Department of Radiology at University of California San Diego. He has been with Roswell Park Cancer Institute, PDT Center, as Assistant Professor since November 2007.

Klappentext
The diffuse optical technique using Near-Infrared (NIR) light provides a promisingmeans for non-invasive imaging and clinical diagnosis of deep tissues. This book focuses on a multi-modal diffuse optical technique combining two qualitatively different methodologies: Diffuse Reflectance Spectroscopy (DRS) and Diffuse Correlation Spectroscopy (DCS). This approach permits real-time, non-invasive and simultaneous quantification of tissue hemoglobin concentration, blood oxygen saturation and blood flow. This book outlines the basic principles, mathematical modeling and then practical instrumentation that enable monitoring of tumor responses to therapies in preclinical and clinical contexts. Targeted audience of this book is scientists who are interested in basic principles of diffuse optics and its applications to translational research and medical doctors who are interested in practical tools for therapy monitoring in clinics.