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UFM1
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Details
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene. UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1) and E2-like conjugating enzyme UFC1. Ufm1 shares several common properties with ubiquitin (Ub) and other ubiquitin-like molecules (UBLs). Ufm1 has similar tertiary structure to Ub but lacks any obvious sequence similarity. It is synthesized as an inactive precursor form (pro-Ufm1) which has 2 additional amino acids beyond the conserved glycine. The mechanism of Ufm1 conjugation is similar to that of ubiquitin. Mature Ufm1 has an exposed C-terminal glycine which is essential for subsequent activation by its cognate E1 protein (Uba5).
Weitere Informationen
- Allgemeine Informationen
- Editor Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
- Titel UFM1
- Format Fachbuch
- EAN 9786131313295
- Größe H220mm x B220mm
- Genre Medizin
- Anzahl Seiten 152
- Herausgeber Betascript Publishing
- GTIN 09786131313295
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