UGT2B4

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene. UGT2B4 is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone. The expression of the UGT2B4 enzyme is upregulated by the farnesoid X receptor (FXR), a nuclear receptor which is activated by bile acids. These same bile acids are substrates for the UGT2B4 enzyme. Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.

Weitere Informationen

  • Allgemeine Informationen
    • Editor Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
    • Titel UGT2B4
    • Format Fachbuch
    • EAN 9786131333019
    • Größe H220mm x B220mm
    • Genre Medizin
    • Anzahl Seiten 140
    • Herausgeber Betascript Publishing
    • GTIN 09786131333019

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