UHRF1
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
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GarantieWeitere Informationen
- Allgemeine Informationen
- Editor Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
- Titel UHRF1
- Format Fachbuch
- EAN 9786131333620
- Größe H220mm x B220mm
- Genre Medizin
- Anzahl Seiten 104
- Herausgeber Betascript Publishing
- GTIN 09786131333620
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