Ulcerative colitis and peptic ulcer imaging

This study aims to evaluate newly labeled compounds that were used as a tracer for ulcerative colitis and stomach ulcer imaging like [99mTc]pantoprazole, [99mTc]omeprazole, [99mTc]rabeprazole, [125I] iodofamotidine, [125I]iodoomeprazole ,[131I]iodorabeprazole [99mTc] mesalamine,[99mTc-olsalazine], and [125I]iodomesalamine. That was labeled with [125I] or [99mTc]. Factors such as the amount of oxidizing agent, amount of reducing agent, amount of substrate, pH, reaction temperature and reaction time, have been systematically studied to optimize the labeling process. The labeled compound was separated and purified using thin layer chromatography (TLC), paper electrophoreses and high performance liquid chromatography (HPLC). The biological distribution indicated that the labeled compounds may be considered a highly selective radiotracer for ulcerative colitis and peptic ulcer imaging that was cofirmed by gamma camera.

Autorentext
Prof. M. H.Sanad received his PhD in Radiochemistry from University of Ain Shams, Egypt and has been associated as a Assistant Prof. at Egyptian Atomic Energy Authority. Dr. Sanad has also worked as a Lecturer at Faculty of Engineering, University of Ain Shams, and he has 40 papers in the field of Nuclear medicine as well.