Unlocking the Power of Cadherins: How EC Repeats Drive Cell Adhesion

The strand-swap trans interaction is further strengthened by a cis interaction between the EC1 repeat of one protomer and the EC2 repeat of another monomer on the surface of the same cell. In this way, type I classical cadherins can form Velcro-like patches on the cell surface34,42. Type II classical cadherins act in a similar fashion, but have two conserved tryptophans (W2, W4), both of which are exchanged between EC1 monomers to form the strand swap43. Desmosomal cadherins have just one conserved tryptophan (W2) in the same position as Type I classical cadherins, but the two types of desmosomal cadherin, desmoglein and desmocollin, are capable of forming heterophilic complexes30 whereas type I and type II classical cadherins are mostly homophilic, though some exceptions exist44,45.

Unlock the secrets of cell adhesion! This book explains how cadherins, with their EC repeats, glue cells together. Essential for scientists and anyone curious about how our bodies work.

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Professor Anya Khansa is a leading authority in the field of HIV/AIDS treatment and prevention. Her dedication to global health equity has driven her extensive research on expanding access to antiretroviral therapy (ART) for improved health outcomes. Professor Khansa's career has been distinguished by impactful work in [areas of Prof Khansa's expertise - e.g., developing treatment programs for key populations, researching the efficacy of TasP strategies, advocating for resource allocation in underserved communities]. Her research has been published in top scientific journals and has directly informed policy changes by [relevant organizations - e.g., WHO, national health ministries]. Professor Khansa's passion extends beyond academia. She is a fervent advocate for [causes Prof Khansa champions - e.g., reducing stigma around HIV, promoting community engagement in healthcare]. Her tireless efforts on the ground, working with [relevant stakeholders - e.g., healthcare workers, patient advocacy groups], have empowered individuals and communities most affected by HIV.