Vaccine Design

This volume provides a practical guide providing step-by-step methods and protocols on vaccine development and production. Divided into three volumes, Volume 3: Resources for Vaccine Development guides readers through chapters on vaccine adjuvants, vaccine vectors, production, vaccine delivery systems, vaccine bioinformatics, vaccine regulation, and intellectual property. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.

Authoritative and practical, Vaccine Design: Methods and Protocols, Second Edition, Volume 3: Resources for Vaccine Development aims to be a useful practical guide to researchers to help further their study in this field.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt
Artificial Intelligence for Vaccine Design.- Progress in the Development of Structure-Based Vaccines.- Polymer-Peptide Conjugate Vaccine for Oral Immunization.- An update on Reverse Vaccinology: The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines.- Phage T7 as a Potential Platform for Vaccine Development.- Plant-based Systems for Vaccine Production.- Production of a Hepatitis E Vaccine Candidate Using the Pichia pastoris Expression System.- Developments in Vaccine Adjuvants.- Adjuvants: Engineering Protective Immune Responses in Human and Veterinary Vaccines.- Cationic Nanostructures as Adjuvants for Vaccines.- Emulsion Adjuvants for Use in Veterinary Vaccines.- Generation of a Liposomal Vaccine Adjuvant Based on Sulfated S-lactosylarchaeol (SLA) Glycolipids.- Glucan particles: choosing the appropriate size to use as a vaccine adjuvant.- Use of Optical In Vivo Imaging to Monitor and Optimize Delivery of Novel Plasmid-Launched Live-Attenuated Vaccines.- Liposomes for the Delivery of Lipopeptide Vaccines.- Current Prospects in Peptide-Based Subunit Nanovaccines.- Design and Synthesis of Protein-based Nanocapsule Vaccines.- Design and Preparation of Solid Lipid Nanoparticle (SLN) Mediated DNA Vaccines.- Nano-Particulate Platforms for Vaccine Delivery to Enhance Antigen-Specific CD8+ T Cell Response.- PilVax: A Novel Platform for the Development of Mucosal Vaccines.- Bioinformatic Techniques for Vaccine Development: Epitope Prediction and Structural Vaccinology.- Immunoinformatic Approaches for Vaccine Designing for Pathogens with Unclear Pathogenesis.- In silico Identification of the B-cell and T-cell Epitopes of the Antigenic Proteins of Staphylococcus aureus for Potential Vaccines.- Computational Mining and Characterization of Hypothetical Proteins of Mycobacterium Bovis towards the Identification of Probable Vaccine Candidates.- Recombinant Vaccine Design against Clostridium Spp. Toxins using Immunoinformatics Tools.- Searching Epitope-based Vaccines Using Bioinformatic Studies.- The Regulatory Evaluation of Vaccines for Human Use.- Intellectual Property Rights and Vaccines.- Vaccine Intellectual Property.- Resources for Starting a Company.