Viral Proteases and Their Inhibitors

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Autorentext
Satya P. Gupta is presently a Professor Emeritus at Meerut Institute of Engineering and Technology (MIET), Meerut, India, after retiring as Professor in the Department of Applied Sciences at National Institute of Technical Teachers' Training and Research (NITTTR), Bhopal. Earlier he served Tata Institute of Fundamental Research (TIFR), Mumbai, a world renowned Institution of India, Birla Institute of Technology and Science (BITS), Pilani, and then (MIET) as its Director-cum Professor of Eminence in the Department of Pharmacy. Professor Gupta has a very long standing of teaching Quantum Chemistry, Pharmaceutical Chemistry, Biophysics, and Drug Design. He had obtained his M. Sc and D. Phil degrees from University of Allahabad, Allahabad, in 1967 and 1971, respectively. He is a world renowned scientist. For his work in Drug Design, he has bagged several honors and awards. To his credit, Gupta has more than 200 research publications in highly reputed national and international journals and several reviews in such highly prestigious periodicals as Chemical Reviews (American Chemical Society), Progress in Drug Research (Birkhäuser Verlag Basel, Switzerland), and Current Medicinal Chemistry (Bentham Science, Netherlands), and has been on editorial board of several international journals. Dr. Gupta himself has been editor of several scientific journals and books of international repute published by Springer Verlag, Heidelberg Germany; CRC Press, Taylor and Francis Group; Nova Science Publishers, NY, USA; and Elsevier (Academic Press), USA. He has delivered several lectures on Drug Design across the world. His scientific activity has brought him on the forefront of scientific community of the world.

Klappentext

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Inhalt

1. Fundamentals of Viruses and Their Proteases
   Anjana Sharma and Satya P. Gupta
   2. Design and Development of Some Viral Protease Inhibitors by QSAR and Molecular Modeling Studies
   Noha Saleh Hanan Elhaes and Medhat Ibrahim
   3. Advances in Studies on Adenovirus Proteases and Their Inhibitors
   Satya P. Gupta Basheerulla Shaik and Y. S. Prabhakar
   4. Alpha-virus Nonstructural Proteases and Their Inhibitors
   Akalabya Bissoyi, Subrat Kumar Pattanayak Arindam Bit Ashish Patel, Abhishek
   5. Structure and Function of Alphavirus Protease
   Shailly Tomar and Megha Aggarwal
   6. Flavivirus Protease: An Antiviral Target
   Shailly Tomar, Rajat Mudgal and Benazir Fatma
   7. Flavivirus NSB/NS3 Protease: Structure, Function, and Inhibition
   Zhong Li Jing Zhang Hongmin Li
   8. Design and Development of HCV NS5B Polymerase Inhibitors
   Debasis Das
   9. Studies on HIV-1 Protease and its Inhibitors
   Sonal Dubey
   10. Studies on Picornaviral Proteases and Their Inhibitors
   Vaishali M. Patil and Satya P. Gupta
   11. Structural Insight into the Viral 3C-like Protease inhibitors: Comparative SAR/QSAR Approaches
   Nilanjan Adhikari Sandip Kumar Baidya Achintya Saha, Tarun Jha
   12. Herpesvirus Proteases: Structure, Function, and Inhibition
   Kriti Kashyap and Rita Kakkar
   13. Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR
   Dimitra Hadjipavlou-Litina and Satya P Gupta
   14. Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance
   Dolly A. Parasrampuria