Virus Host Cell Genetic Material Transport

The reproduction and spread of a virus during an epidemic proceeds when the virus attaches to a host cell and viral genetic material (VGM) (protein, DNA, RNA) enters the cell, then replicates, and perhaps mutates, in the cell. The movement of the VGM across the host cell outer membrane and within the host cell is a spatiotemporal dynamic process that is modeled in this book as a system of ordinary and partial dierential equations (ODE/PDEs).

The movement of the virus proteins through the cell membrane is modeled as a diffusion process expressed by the diusion PDE (Fick's second law). Within the cell, the time variation of the VGM is modeled as ODEs. The evolution of the dependent variables is computed by the numerical integration of the ODE/PDEs starting from zero initial conditions (ICs). The departure of the dependent variables from zero is in response to the virus protein concentration at the outer membrane surface (the point at which the virus binds to the host cell).

The numerical integration of the ODE/PDEs is performed with routines coded (programmed) in R, a quality, open-source scientic computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The ODE/PDE dependent variables are displayed graphically with basic R plotting utilities.

The R routines are available from a download link so that the example models can be executed without having to rst study numerical methods and computer coding. The routines can then be applied to variations and extensions of the ODE/PDE model, such as changes in the parameters and the form of the model equations.

Provides a detailed discussion on the reproduction and spread of a virus during an epidemic Presents research findings through detailed examples, rather than formal mathematics, so that the reader can execute themselves on modest computers Routines are programmed in R, a quality open-source computing system that is readily available as a download from the internet

Autorentext
William E. Schiesser is Emeritus McCann Professor of Computational Biomedical Engineering, Biomolecular and Chemical Engineering, and Professor of Mathematics at Lehigh University.

Inhalt

1. Virus Protein ODE/PDE Models.- 2. Implementation of the ODE/PDE Models.- 3. Host Cell Proteins with Cross Diffusion.- 4. Postulated Vaccine and Therapeutic.- 5. Detailed ODE/PDE Model Analysis.