Wilms' tumor gene 1 as an immunotherapeutic target in uterine cancer

Uterine high grade sarcoma and recurrent endometrial carcinoma are aggressive cancers with limited classical treatment options, resulting in a poor prognosis. The search for targeted treatments is urgently needed. In this research we focused in the first place on the detection of the highly immunogenic tumor-associated antigen Wilms tumor gene 1 (WT1) in uterine tumors. The next step was to develop a targeted treatment against WT1, based on dendritic cell immunotherapy.

Autorentext

During her PhD, An Coosemans (°1980) developed dendritic cell immunotherapy in uterine cancer. As a gynaecologist, she is now guiding dendritic cell immunotherapy trials in uterine cancer and is setting up models to study dendritic cell immunotherapy in ovarian cancer. She is married and mother of two daughters.