XLF

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Details

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. XLF (XRCC4-like factor), also known as Cernunnos, is a protein encoded by the human NHEJ1 gene. XLF was originally discovered as the protein mutated in five patients with growth retardation, microcephaly, and immunodeficiency. The protein is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Patients with XLF mutations also have immunodeficiency due to a defect in V(D)J recombination, which utilizes NHEJ to promote immune system diversity. XLF interacts with DNA ligase IV and XRCC4 and is thought to be involved in the ligation step of NHEJ. The yeast (Saccharomyces cerevisiae) homolog of XLF is Nej1.

Weitere Informationen

  • Allgemeine Informationen
    • GTIN 09786131026720
    • Editor Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
    • Größe H220mm x B220mm
    • EAN 9786131026720
    • Format Fachbuch
    • Titel XLF
    • Herausgeber Betascript Publishing
    • Anzahl Seiten 104
    • Genre Biologie

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