Zebrafish at the Interface of Development and Disease Research: Volume 124

Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others.

Autorentext
Dr. Kirsten Sadler Edepli is a cell biologist and geneticist whose research focuses on the molecular basis of liver development and two important liver diseases, liver cancer and fatty liver disease. After studying biology and Anthropology at Mount Holyoke College in MA, she obtained a Masters in Medical Sciences at Harvard Medical School (1994) and a Ph.D. in Cell and Developmental Biology at Harvard University (1998). She joined the faculty at Bosphorus University in Istanbul/Turkey and then moved to work with Nancy Hopkins at MIT where she screened for zebrafish mutants with liver disease and growth defects. She started her lab as assistant professor in Departments of Medicine and of Developmental and Regenerative Biology at The Icahn School of Medicine at Mount Sinai in New York in 2006, where she was promoted to associate professor in 2013. In 2015, she joined the faculty of New York University in Abu Dhabi as a tenured associate professor in the Biology Program. She runs an active research group focused on epigenetic control of liver development, regeneration and cancer and on the fatty liver disease. She teaches, is an active member of the NYU academic community, and serves her passion of promoting gender equity in science, technology, engineering and math (STEM) through a range of activities, including serving as the faculty advisor for Women Empowered in STEM at NYUAD.

Klappentext

There are many shared pathways that govern development and also can contribute to disease. Zebrafish have traditionally been used to study vertebrate development, and from decades of work in this system, we have learned details about developmental processes, genes and pathways that are implicated in disease. In each chapter of this book, we interweave how studying zebrafish development has informed our understanding of diseases from the immune system, to the kidney, liver, heart and others.--

Inhalt

1. Modeling Syndromic Congenital Heart Defects in Zebrafish M.G. Grant, V.L. Patterson, D.T. Grimes and R.D. Burdine 2. Using Zebrafish to Study Kidney Development and Diseas S. Jerman and Z. Sun 3. Zebrafish Developmental Models of Skeletal Diseases L.N. Luderman, G. Unlu and E.W. Knapik 4. Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish W. Kwan and T.E. North 5. Making it New Again: Insight into Liver Development, Regeneration, and Disease from Zebrafish Research S. Wang, S.R. Miller, E.A. Ober and K.C. Sadler 6. 'Muscling' Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish M.F. Goody, E.V. Carter, E.A. Kilroy, L. Maves and C.A. Henry 7. Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies V.E Prince, R. Anderson and G. Dalgin 8. Modelling Infectious Diseases in the Context of a Developing Immune System S. Masud, V. Torraca and A.H. Meijer 9. Zebrafish in Toxicology and Environmental Health K. Bambino and J. Chu